CuSO4·5H2O/NaAsc-Catalyzed Sonogashira Coupling Reaction of Aryl Iodides and Terminal Alkynes
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چکیده
منابع مشابه
Ligand-, copper-, and amine-free sonogashira reaction of aryl iodides and bromides with terminal alkynes.
Conditions for an efficient ligand-, copper-, and amine-free palladium-catalyzed Sonogashira reaction of aryl iodides and bromides with terminal alkynes have been developed. Critical to the success of this new protocol is the use of tetrabutylammonium acetate as the base. Noteworthy features of this method are room-temperature conditions and the tolerance of a broad range of functional groups i...
متن کاملPalladium-catalyzed carbonylative Sonogashira coupling between aryl triazenes and alkynes.
We developed a palladium-catalyzed carbonylative Sonogashira reaction with aryl triazenes and alkynes as substrates and methanesulfonic acid as the additive. A series of α,β-ynones were synthesized by this alternative procedure. Notably, bromides, iodides and hydroxyl groups could be well-tolerated under these reaction conditions.
متن کاملEfficient palladium-catalyzed homocoupling reaction and Sonogashira cross-coupling reaction of terminal alkynes under aerobic conditions.
An efficient method for palladium-catalyzed homocoupling reaction of terminal alkynes in the synthesis of symmetric diynes is presented. The results showed that both Pd(OAc)(2) and CuI played crucial roles in the reaction. In the presence of 2 mol % Pd(OAc)(2), 2 mol % CuI, 3 equiv of Dabco, and air, homocoupling of various terminal alkynes afforded the corresponding symmetrical diynes in moder...
متن کاملAn efficient LDH-Pd-catalyzed three-component coupling of aryl iodides, alkynes and alkenes
A three-component coupling of aryl iodides, alkynes, and alkenes to generate 1,3-butadiene derivatives using layered double hydroxides supported nanopalladium (LDH-Pd) catalyst is described. LDH-Pd was recovered quantitatively by simple filtration and reused several times with almost consistent activity. 2006 Elsevier B.V. All rights reserved.
متن کاملPalladium-catalyzed asymmetric coupling cyclization of terminal γ-allenols with aryl iodides.
A Pd-catalyzed asymmetric coupling cyclization of γ-allenols has been developed. Styrenyl derivatives can be prepared in 60-86% yields with ee values ranging from 85-92%.
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ژورنال
عنوان ژورنال: Chinese Journal of Organic Chemistry
سال: 2017
ISSN: 0253-2786
DOI: 10.6023/cjoc201701013